Michael J. Econs
- Titled Professor (2007)
- Glenn W. Irwin, Jr. Professor of Endocrinology and Metabolism
Indiana University Purdue University Indianapolis (IUPUI)
School of Medicine
Department of Medicine
BIOGRAPHYMichael J. Econs, MD, a graduate of John Hopkins University and University of California, is board certified in both Internal Medicine and Endocrinology. Following a residency at the University of Baltimore, Dr. Econs completed his Endocrinology and Metabolism Fellowship at Duke University Medical Center. After his fellowship in 1990, Dr. Econs stayed on at Duke University Medical Center as an Associate Professor of Medicine until 1997. While at Duke University Medical Center he received the ASBMR Young Investigators Award in 1990 and the Young Investigator Award: Advances in Mineral Metabolism in 1991. Dr. Econs joined Indiana University Medical Center in 1997 and served as an Associate Professor of Medicine until 2002. In 2001 he became Division Director of the Division of Endocrinology and Metabolism and still serves in that role presently. In 2002, he was promoted to Professor of Medicine and Medical and Molecular Genetics. In 2000, Dr. Econs was awarded the Boy Frame Award, Adult Bone and Mineral Working Group from ASBMR.
Dr. Econs' primary area of interest is the genetic aspects of metabolic bone diseases. Current projects include clinical and genetic studies of autosomal dominant hypophosphatemic rickets (ADHR) and autosomal dominant osteopetrosis as well as a study that focuses on the genetic determinants of bone fragility in normal individuals. Previous efforts have led to the identification and cloning of PHEX (the gene responsible for X-linked hypophosphatemic rickets); FGF23 (responsible for ADHR); ClCN7 (responsible for autosomal dominant osteopetrosis); as well as determining that activating mutations in FGFR1 are responsible for Osteoglophonic dysplasia. The lab is currently performing functional studies of FGF23 to determine its role in normal physiology as well as its role in other diseases of phosphate homeostasis. Studies in osteopetrosis focus on understanding the mechanisms of nonpenetrance. Studies of the genetic aspects of bone fragility focus on understanding the genetic determinants of peak bone mass in men and women and bone loss in women. He is internationally renowned in his field of research and has participated in over 40 invited guest lectures and he has written and published over 70 manuscripts in this area of research.
Dr. Econs' clinical interests are also in the field of metabolic bone diseases. He treats a number of patients with tumor induced osteomalacia, osteoporosis, osteopetrosis, Paget's disease, hyperparathyroidism, hypoparathyroidism, autosomal dominant hypophosphatemic rickets, and x-linked hypophosphatemia, etc.